This study examined the physico-chemical properties and concentrations of lead (Pb) and chromium (Cr) in agricultural soils adjacent to Pb and granite mine-sites in Agoi-Ibami (Yakurr LGA) and Ohana (Obubra LGA), Cross River State, Nigeria. Soil samples were collected at 0 – 15 cm and 15 – 30 cm to represent surface and sub-surface soils, respectively. Soil samples were collected at 100, 200, 300 and 1000 m (control) away from the mine-pits. Particle size distribution indicates the dominance of sand (> 50%) over silt and clay while soil pH was strongly acid (5.1 – 5.5) in AI and slightly acid (6.1 – 6.5) in OHA. Organic carbon was moderate to high (> 0.5%) in all locations while exchangeable Ca and Mg were moderate in the soils, whereas cation exchange capacity exceeded 35 cmol/kg and rated high but with low base saturation (< 40%). Lead concentration ranged from 9.86 to 96.04 in AI, and 0.20 to 20.12 mg/kg in OHA, while chromium ranged from 1.65 to 10.34 mg/kg in AI and 1.81 to 8.26 mg/kg in OHA. Lead and chromium concentrations were higher in the control sites than in soils closer to the mines, especially at 300 m. The study concludes that mining activities significantly influence potentially toxic elements enrichment in nearby farmlands and recommends regular monitoring, phytoremediation, vegetation buffer zones, soil amendments, and stricter environmental regulation to mitigate risks.